Molecular Analysis of 185delAG and 6174delT Mutations in Eastern Indian Breast Cancer Cases

Breast cancer (BC) is a form of cancer in the glandular breast tissue. In India, women diagnosed with carcinoma of the breast is on an average of 80,000 and women die of this disease every year is 40,000, and it is marked as the second most common cancer among Indian women (19%) after cervical cancer (30%) (Saxena et al. 2006). For the development of breast and ovarian cancers there may be several factors responsible, but the presence of BRCA1 and BRCA2 (breast cancer predisposition gene 1/2) gene mutations is the most significant which has been described so far .5%-10% of the recorded cases accounts for only hereditary breast cancer, in which 80-90% comprises lifetime risk for the individuals with mutations in these genes of breast cancer and 40-50% lifetime risk of ovarian cancer (Claus et al., 1991; Easton et al., 1995; Somasundaram 2010). Even after understanding of the fact how BRCA1 and BRCA2 mutations could influence cancer susceptibility which was achieved after several attempts of studies, the variation in risk among carriers of these mutations is not yet clear. It has been noted that